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Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
(The most common side effects of GLP-1s are gastrointestinal.) We should always keep evaluating their safety, but we have a good understanding of what this class of medicine does, and it has a pretty favorable risk-benefit ratio, Drucker says
Eating smaller, more frequent meals can help reduce this discomfort
Early in tirzepatide treatment, before significant weight loss has occurred but while GI side effects are causing fluid shifts, blood pressure can fluctuate unpredictably
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